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Farhan Abdullah, DO | Medical Director, Magnolia Functional Wellness | Southlake, TX Last week a patient sat across from me and said something I hear constantly: "I've lost 30 pounds on tirzepatide, but I still can't get rid of this stubborn pouch around my midsection." She wasn't imagining it

The most recognizable physical signs of high cortisol include: Weight gain around the abdomen and lower back that does not respond to diet or exercise A rounded, puffy face, sometimes called cortisol face Thinning skin that bruises easily Slow wound healing High blood sugar or worsening insulin resistance High blood pressure Frequent infections from a suppressed immune system These physical changes happen because cortisol in excess breaks down muscle tissue for fuel, promotes fat storage in the midsection and keeps blood sugar chronically elevated