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Pharmacological strategies include metformin to improve IR and correct associated metabolic abnormalities, combined oral contraceptive pills (COCPs) for regulating menstrual cycles and HA, and if needed, anti-androgens for refractory HA ( Resveratrol, a natural polyphenolic compound found in plants such as peanuts, grapes, knotweed, and mulberries ( 2 Resveratrol improves abnormal glucose metabolism IR and compensatory hyperinsulinemia are observed in 65%-95% of women with PCOS, encompassing the majority of overweight/obese individuals and over half of normal-weight women ( Emerging preclinical evidence demonstrates that one-month resveratrol treatment normalizes estrous cyclicity in letrozole-induced PCOS rodent models

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In addition, the basal GLP-1 secretion was significantly inhibited by 1-M pasireotide treatment in GLUTag cells, and the inhibitory effect of pasireotide was reversed by PTX treatment (Fig