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The main reason is receptor desensitization : continuous stimulation of the same receptor makes cells less responsive over time, so a planned off period lets the receptor resensitize

There is some evidence that long-term corticosteroid use can increase the risk of cataracts and glaucoma, although this is more common with oral or injected steroids

31 Since there is significant residual CVD risk in patients with diabetes, even after accounting for traditional risk factors, the development of novel therapeutic avenues is needed to address it

The impact of biotechnology products on pharmaceutical industries and new therapeutics can be illustrated by the fact that a remarkable percentage of recent drug approvals by the FDA are in the biological category (recombinant proteins and peptides, monoclonal antibodies, etc.)