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For example, elongated particles with larger contact surfaces tend to be less effective at lung targeting, as their shape promotes stronger van der Waals forces and aggregation 131

Excessive agitation can introduce foam and unnecessary mechanical stress

References [1] National Library of Medicine, Enhancing the Oral Bioavailability of Glutathione Using Innovative Analogue Approaches, Yin, N., Harris, P.W.R., Liu, M., Sun, J., Chen, G., Wen, J., Brimble, M.A., March 2025