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Oxidative stress, inflammation, and microvascular dysfunction are recognized key contributors to BPH pathogenesis, creating an environment conducive to structural remodeling and impaired tissue homeostasis

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Depression and the MTHFR Gene Variants: A1298C and C677T A meta-analysis of 26 studies found that the MTHFR C677T variant was associated with an increased risk of depression.[ref] Age and gender may also play a role here

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