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48,61 Fibromyalgia has been associated with higher serum levels of tumor necrosis factor (TNF)-alpha, substance P, and corticotropin-releasing hormone (CRH), all of which play a role in mediating inflammation

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Research Overview Nicotinamide N-methyltransferase (NNMT) catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (SAM) to nicotinamide, producing 1-methylnicotinamide and S-adenosyl-L-homocysteine [1]