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[DOI] [PMC free article] [PubMed] [Google Scholar] 97.Xia H., Lazartigues E

Oxidative stress does not occur randomly it is driven upward by: undermethylation copper overload immune activation high sugar diets nutrient deficiencies sleep disruption physical or emotional stress environmental exposures When antioxidants are low, the brain cannot: regulate sensory input maintain mitochondrial energy detoxify inflammatory byproducts stabilize mood or attention manage stress hormones This creates a vulnerability window a period in which developmental timing can be disrupted by ordinary childhood stressors

11 (3): pii: E317