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In the Krebs cycle, adenosylcobalamin can induce the accumulation of succinate, an antagonist of histone and DNA demethylation reactions catalyzed by enzymes of the 2-oxoglutarate-dependent dioxygenase family, which may favor the activation or inhibition of gene expression ( Figure 5 )

When looking at the entire group, the weight change after 14 weeks was minimal in the placebo group (+0.5%), but the TE groups showed weight reductions of -0.5%, -0.9%, -1.32%, and -2.32% for different doses of TE

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They used this technology to design VBI-2901 , a vaccine that expresses a modified prefusion form of spike proteins from SARS-CoV-2, SARS-CoV-1, and MERS-CoV