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Rats made diabetic by injection of streptozotocin are hyperabsorbers of cholesterol which was explained by changes in intestinal absorption-regulating proteins, namely, an upregulation of NPC1L1, ACAT2, and microsomal triglyceride transfer protein (MTP) and a reduced expression of ABCG5 and ABCG8 [91]

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Descriptive statistics were performed for the comparison between cases and controls

Vitamin B12 deficiency can occur less frequently as a result of nutritional habits (strict vegans, breastfed infants born to vegan mothers with reduced dietary intake of animal products), drug interference (metformin, proton pump inhibitors, drug-affected purine, and pyrimidine synthesis), inherited disorders affecting intrinsic factor (IF) and other inherited disorders including methylmalonic acidemia and transcobalamin II deficiency nitrous oxide abuse, Diphyllobothrium latum infection, and pancreatic insufficiency.[] Metformin is considered a cornerstone in the treatment of diabetes and is the most frequently prescribed first-line therapy for individuals with type 2 diabetes