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The sequence of kinase domain of RIPK1 (RIPK1 1-324) was used for prediction and the phospho-S309 was also introduced

In terms of NLRP3 inhibitors, tranilast, a clinically approved anti-allergic drug with additional anti-inflammatory effects inhibiting NLRP3 inflammasome activation by disrupting the mammalian NIMA-related kinase 7 (NEK7) interaction, 224,225 has been confirmed to exhibit significant preventive and therapeutic efficacy in mouse models of NLRP3 inflammasome-mediated human pathologies, e.g., gouty arthritis and type 2 diabetes

GMO-free Suggested Use: Adults should take 1 teaspoon daily in water or juice before breakfast

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