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In the muscles, accumulated ammonia interferes with energy production, leading to premature exhaustion, heavy limbs, and deep muscle aching

Recently, extracellular matrix derived from mesenchymal stem cells were shown to maintain re-differentiation potential of human chondrocytes ( Conclusion In vitro expanding human chondrocytes to a number that is required by the ACI results in the generation of senescent cells

Zhang G, Wang X, Li C, Qinfeng Li YuA, An XL, Deng Y, Gillette TG, Scherer PE, Wang ZV (2021) Integrated stress response couples mitochondrial protein translation with oxidative stress control