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doi:10.1007/s13311-019-00767-8 Lejri I, Grimm A, Eckert A

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The most cited mechanistic finding is the Neelakantan and colleagues 2018 study in Biochemical Pharmacology , in which the investigators reported that 5-Amino-1MQ reverse[s] high fat diet-induced obesity in mice through selective inhibition of the NNMT enzyme, with measurable reductions in adipose tissue mass, improvements in insulin sensitivity, and increases in adipose tissue cellular metabolic activity in C57BL/6 mice fed a 60% kcal-from-fat diet [1]

For individuals whose primary concern is liver health rather than (or in addition to) weight loss, this data point may be decisive