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Further, the applicant explained that it did not assert that the VersaVue TM Single-Use Flexible Cystoscope offers a substantial clinical improvement compared to other single-use cystoscopes, stating that the substantial clinical improvement claims and evidence provided were in support of the category of single-use cystoscopes compared to reusable cystoscopes rather than the VersaVue TM Single-Use Flexible Cystoscope compared to other single-use, disposable cystoscopes or reusable cystoscopes

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369,370 Genetic disruption of GLP-1R signaling leads to cortical osteopenia and heightened bone fragility, primarily caused by increased bone resorption by osteoclasts

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