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Therefore, AD is linked with significant alterations of THs due to inhibition of the peripheral conversion of T4 to T3

Kremer et al., 2024) with an indispensable role of STAT3 activation due to methylation at a CpG site in the GFAP promoter (Takizawa et al., 2001), and in TET1/2/3-mediated DNA demethylation for establishing neural stem cell identity and enabling glial (e.g., astrocyte and oligodendrocyte) differentiation (MacArthur et al., 2024)

Phytochemical analysis Different parts of Jamun, including the roots, stems, leaves, fruits, and seeds, are reported to synthesize several phytochemicals (Table 2).2548 The water, ethanol, chloroform, ethyl acetate, hexane petroleum ether, and methanol extracts of Jamun leaves contain high-to-low amounts of anthraquinones, alkaloids, cardiac glycosides, flavonoids, glycosides, phenols, steroids, saponins, tannins, proteins, triterpenoids, phytosterols, mucilage, amino acids, carbohydrates, fixed oils, volatile oil, terpenoids, and fats

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