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The same sections were independently evaluated by two observers who were blinded to the groups

doi: 10.1126/science.aau6323 171

Loss of Cathepsin D leads to lysosomal dysfunction and the accumulation of various cellular proteins associated with neurodegenerative diseases

The knockdown of microglial S100A8, a protein mediating cellular damage by enhancing oxidative stress and autophagy, was shown to inhibit the expression levels of ROS, MDA, and ferroptotic indicators, namely ACSL4, NOX2, and 15-LOX ( 2.3 T cells The delicate equilibrium between the activation and elimination of T cells is finely tuned to ensure efficacious immune responses and avert autoimmune diseases