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Without long-term human studies, its safety profile remains largely unknown

212 Nevertheless, semen analysis does not identify all male infertility cases, since even in the context of normal findings, sperm may be unable to reach the female germ cell, fertilize it, or contribute to a healthy pregnancy

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These verdicts characterize the regulation of sortilin shedding and identify a novel mechanism by which sortilin ectodomain shedding acts as a regulatory switch for delivery of BDNF to the secretory pathway or to the lysosome, thus modulating the bioavailability of endogenous BDNF (Fig