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johnsonii ) reduce protective IAld, elevating toxic IAA and indoxyl sulfate, which accelerate renal damage ( Bacteroides ) perturb metabolites like glycocholenate sulfate and -ketoglutarate, directly influencing diabetic nephropathy progression ( Lactobacillus ) normalizes tryptophan-derived metabolites, inhibiting AhR and offering therapeutic strategies for kidney diseases ( Figure 1 )