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The xenobiotic adaptation in arthropods evolves through multiple mechanisms (Figure 1) [13, 14], including reduced penetration through the cuticle, behavioral avoidance [15, 16], microbiome-mediated detoxification [17-20], enhanced metabolic detoxification [21-25], enhanced sequestration or excretion [13, 19, 26, 27], and target site insensitivity [28-32]

Adipose tissue can directly express hepcidin and can also indirectly regulate the expression of hepcidin through the levels of leptin and proinflammatory cytokines to affect iron balance

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