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This document from NHS England put the total number as of 2020, for the UK, at 9.15 million people

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NICE guidelines are evidence-based recommendations for health and care in England and Wales

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One of the major drawbacks is their large molecular mass of about 150 kDa, responsible for slow kinetics and limited tumor penetration with only approximately 20% of the administered dose reaching the tumor site [85]

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Challenges Some practices may find it difficult to implement the changes due to lack of time, resources, or bandwidth

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