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Bimix, Trimix, and even Quadmix injections are an option for patients who do not respond to oral therapy

JAMA Netw Open 2024

Studies suggest that berberine, one of the main compounds in goldenseal, may reduce sugar absorption from the gut, lower insulin resistance, and promote insulin secretion all of which are factors that may help lower blood sugar levels ( Research further suggests that the blood-sugar-lowering effects of berberine may be as effective as those of metformin, a common antidiabetic medication ( Moreover, the combination of berberine with blood-sugar-lowering medication appears to be more effective than taking blood-sugar-lowering medications on their own ( However, although the benefits of berberine appear promising, its unclear whether the amount of berberine in goldenseal is sufficient to produce the same effects