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In ASD, an EWAS study on histone acetylation in participants with the disorder compared to controls found an enrichment of hyperacetylated sites in genes involved in GABA receptor activity (Ramaswami et al., Reference Ramaswami, Won, Gandal, Haney, Wang, Wong and Geschwind2020), although this has not been previously found on DNAm (Wong et al., Reference Wong, Smith, Hannon, Ramaswami, Parikshak, Assary and Sun2018)

Studies in healthy individuals have shown that physical activity enhances kynurenine metabolism within muscle, but it remains unclear whether these effects are replicated in cancer patients or whether they are sufficient to reduce depressive symptoms in this population [180, 181]

This hyperglycemia may also alter gene and protein expression, endothelial cell permeability, and depletion of antioxidant molecules, including Glutathione S-transferases (GSTs), which play an important role in the cellular detoxification process [37, 41, 43, 44, 45]

In: Conn's Current Therapy 2020