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Dry desert air causes constant fluid loss through breathing and evaporation, and alcohol adds dehydration, mineral depletion, and oxidative stress

The two mutated mouse models represent an unbound form of IGF-1 with impaired post-translational control and increased bioavailability

While ROS display varying reactivities toward different targets, they share the ability to damage cells by oxidizing proteins, lipids and DNA

Further analysis of these metabolic regulatory networks will not only deepen our understanding of the mechanisms behind tumor metabolic reprogramming but also offer novel insights for developing targeted therapeutic strategies against cancer metabolism