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2022;185:37893806.e17

Therefore, by activating this NCOA4-mediated ferritinophagy pathway, Erastin promotes the release of free iron, which in turn amplifies ROS production and lipid peroxidation, resulting in an autophagy-dependent mode of ferroptosis

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IL-15, which is involved in the activation and maturation of anti-tumour T cells, including natural killer (NK) cells and CD8+ T cells (76), was demonstrated to be significantly increased following metformin treatment