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doi: 10.1016/j.it.2016.01.002 86 JiangYHuZHuangRHoKWangPKangJ

It takes approximately 4 to 5 weeks for the drug to reach a steady level in the body, and total effects may not be apparent for at least two months after treatment begins

In this context, Colasanti and coworkers have identified to homocysteinylated A1AT (Hcy-A1AT) in 54.4% of seropositive RA, but not in seronegative cases, indicating their potential relevance in the disease (94)

The authors speculated that variations in participant characteristics, such as age or gender, might account for discrepancies between their findings and those of previous studies