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In the context of breast cancer mouse models, fibroblasts within lung metastases express cyclooxygenase 2 and produce PGE2

doi: 10.1080/00207450902782083 206 KowalczykP.KaczyskaK.KleczkowskaP.Bukowska-OkoI.KramkowskiK.SulejczakD

In Th17 cells in particular, IGF-1 signaling also reduces mitochondrial membrane potential and reduce ROS production, which is particularly damaging to Th17 cells

Ajani has received honoraria from Lilly, Bayer, Novartis, Five Prime Therapeutics, Taiho Pharmaceutical, Genentech, and Roche, received research funding from Novartis, Bristol-Myers Squibb, Taiho Pharmaceutical, Roche/Genentech, MedImmune, Amgen, Lilly/ImClone, Merck, Delta-Fly Pharma, Gilead Sciences, and Takeda, and received travel accommodation expenses (not for this work) from Novartis, Bayer, and Five Prime Therapeutics