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Harding (1985) "The brain RAS and Alzheimer's disease." Exp Neurol 223(2): 326-33

For N-Acetyl Epithalon Amidate specifically, these modifications preserve the core AEDG sequence while engineering the compound for greater persistence in experimental systems

The mechanism is plausible (direct delivery should theoretically accelerate results), but the evidence base is not comparable to what exists for topical application

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