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CJC-1295 with DAC (Drug Affinity Complex) carries a maleimide linker that binds covalently to serum albumin, extending plasma half-life to approximately 68 days and producing a sustained GHRH-receptor signal

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Figure 4 In various experimental systems, including two-dimensional cultures, three-dimensional spheroids, organoids, xenografts, residual disease models, and patient-derived samples, DTP cells consistently share three defining properties: the ability to survive high or prolonged exposure to drugs, entry into a reversible slow-cycling or inactive state, and recovery of proliferative capacity and drug sensitivity after treatment withdrawal