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The G 2 accumulation checkpoint is independent of ATM, but dependent on dose and ensures that cells that pass through earlier cell-cycle phases with DNA damage do not enter mitosis (Xu et al, 2002) The G 2 arrest following exposure to ionizing radiation probably allows damaged DNA to be repaired prior to mitosis since DNA repair activity has been detected during the radiation-induced G 2 delay and has been related to cellular radiosensitivity (Nagasawa et al, 1994

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doi: 10.1172/jci.insight.170428 82 GentryECCollinsSLPanitchpakdiMBelda-FerrePStewartAKCarrillo TerrazasMet al