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Graphical Abstract Similar content being viewed by others Background Ferroptosis, a regulated type of cell death resulting from iron-dependent lipid peroxidation, has been recognized as a crucial mechanism associated with the development of various diseases, including neurodegenerative, cardiovascular, digestive, musculoskeletal, and cancer-related diseases [1]

Advantages of molecular docking and dynamics simulations, X-ray crystallography, and cryo-electron microscopy have facilitated the discovery of allosteric sites to enhance our understanding of allosteric modulation

The combination of NAD+ and glutathione may support overall cellular recovery and regeneration through complementary energy and antioxidant pathways, though direct head-to-head human trials of the combination are still limited

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