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injected into the tail vein and blood samples drawn for analysis using an established ELISA that specifically capture the N-terminal nanobody and detects the C-terminal HSA for Albu-LiTE constructs or the C-terminal His-tag for the LiTE

The lack of BBB penetrating AT 4 receptor agonists and antagonists has limited our understanding concerning the relative importance of brain AT 1 and AT 4 receptor subtypes in the etiology and treatment of dementias, stroke, and related memory dysfunctions

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