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P.RamkumarV

In BCATi-treated Mmut p.L690Ins/p.L690Ins mice, M0 C3 was elevated in liver and plasma compared with Mmut WT/WT controls (Figure 7E), but C3 levels were not different in BCATi-treated compared with untreated Mmut p.L690Ins/p.L690Ins mice

Pharmacological inhibitors of cGAS or STING are under development and have shown efficacy in reducing inflammation in autoimmune and neurodegenerative models