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Vitamin B12 is involved in the metabolism of every cell of the human body, especially affecting DNA synthesis and regulation, but also fatty acid synthesis and energy production

388 Nrf2 inhibition Nrf2, frequently overexpressed in therapy-resistant cancers, represents a promising therapeutic target for ROS-mediated anticancer strategies, as demonstrated by Tamoxifen-resistant breast cancer cells that develop irradiation cross-resistance through Nrf2-driven antioxidant upregulation and a glycolytic shift, with Nrf2 inhibition restoring radiosensitivity in both cellular models and patient tumors (NCT00738777)

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Recently, oleuropein, a polyphenol, was shown to have the senolytic potential in OA chondrocytes (Varela-Eirn et al., 2020)