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Some studies revealed that because of high concentration in plasma, UA can act as a pro-oxidant within the cell by scavenging and creating ROS or it can act as an antioxidant, which mainly occurs in plasma [122,123,124]

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TAK1 phosphorylates and activates the IB kinase (IKK) complex and MAPK kinases (MKKs), which in turn stimulates nuclear factor kappa B (NF-B) and activator protein 1 (AP-1) transcriptional activity leading to inflammation and cell survival (Mihaly et al., 2014)