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This therapeutic effect is achieved through the cleavage of disulfide bonds [33] within mucoproteins (strongly cross-linked mucins), [34] thereby decreasing the mucus viscosity and facilitating its clearance from the respiratory tract

For this reason, several novel NBDHEX analogues, with improved selectivity for GSTP1-1, have been synthesized and characterized to obtain new therapeutic opportunities for the treatment of drug resistant tumors including human melanoma 100,101

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