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Herein, we review key features of curcumin involved in biology, pharmacology, and medicinal chemistry and discuss its potential relevance to pathophysiological progress of multiple sclerosis[7] Curcumin, a component of turmeric, has been shown to be non-toxic, to have antioxidant activity, and to inhibit such mediators of inflammation as NFkB, cyclooxygenase-2 (COX-2), lipooxygenase (LOX), and inducible nitric oxide synthase (iNOS)[8] In a larger, randomized, double-blind, multicenter trial involving patients with quiescent ulcerative colitis, administration of 1 g of curcumin twice daily resulted in both clinical improvement and a statistically significant decrease in the rate of relapse[9] Our results indicate that curcumin has the potential to protect against cardiac inflammation and may provide a novel therapeutic strategy for autoimmune myocarditis [10] In various chronic illnesses in which inflammation is known to play a major role, curcumin has been shown to exhibit therapeutic potential

This approach makes intuitive sense because the amount of incretin stimulation needed to maintain a lower weight is probably less than the amount needed to achieve that lower weight in the first place