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Exercise enhances body composition outcomes: Weight lost through caloric restriction alone (whether drug-assisted or not) typically consists of approximately 25-35% lean tissue

This represents a key mechanism by which tirzepatide produces greater weight loss than diet alone despite similar caloric restriction

Boonen S, Rosen C, Bouillon R, Sommer A, McKay M, Rosen D, Adams S, Broos P, Lenaerts J, Raus J, Vanderschueren D, Geusens P

The results during the therapy and post-treatment periods demonstrated improvements in visual and auditory evoked potentials, but no motor improvements were observed [138]