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Overall, expression levels of all four genes were higher in HepG2 ATP7B-KO cells than in HepG2 cells, although at 0.6mmol/l CuCl, PLA2G2A expression in HepG2 ATP7B-KO cells matched HepG2 levels after 24 h

Moreover, elevated homocysteine levels have been associated with enhanced in vivo lipid and protein oxidation in humans, as suggested by the correlation obtained between plasma homocysteine and F 2 -isoprostanes, relevant biomarkers of nonenzymatic peroxidation (Ventura et al, 2000

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This process will continue to propagate until two radicals combine to form a stable product, or until the radicals are neutralized by a chain breaking antioxidant