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[3] So the two molecules embody two strategies that converged on the same goal from opposite engineering philosophies: cagrilintide adds a separate hormone (amylin) intended to be combined with an incretin, while retatrutide packs an additional receptor activity (glucagon) into the incretin molecule itself

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Abbreviations CLA: Conjugated linoleic acids MDA: Malondialdehyde FBG: Fasting blood glucose c9, t11: Cis9, trans11 t10, c12: Trans 10, cis 12 HbA1c: Glycated hemoglobin A hs-CRP: High sensitivity C-reactive protein NF-B: Nuclear factor kappa B TAC: Total antioxidant capacity TNF-: Tumor necrosis factor- IFN-: Interferon gamma GLUT-4: Glucose transporter 4 PPAR-: Peroxisome proliferator-activated receptor gamma WC: Waist circumference CAT-1: Carnitine-palmitoil-transferase-1 References Peyman N, Rezai-Rad M, Tehrani H, Gholian-Aval M, Vahedian-Shahroodi M, Miri HH

Adv Tech Stand Neurosurg 49:95122