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The hallmark of the PPHN pathophysiology is increased pulmonary vascular resistance (PVR) resulting in decreased pulmonary blood flow (PBF) and hence, decreased amount of oxygenated blood returning to left side of the heart leading to hypoxia, decreased end-organ perfusion, acidosis and cyanosis (9)

[DOI] [PubMed] [Google Scholar] 84.Sonboli A., Babakhani B., Mehrabian A.R

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Typically, this process involves either the loss of hydrogen atoms or the addition of oxygen atoms to the melatonin molecule