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Danny Ruijters: employed by Philips Healthcare

Boosting energy supplies produces excess free radicals from increased oxidative phosphorylation [14] which may not be neutralized if the cells have been operating in a low redox capacity with low activation of Antioxidant Response Elements (ARE) genes

Among these, SPIONs represent a distinct class of nanomaterials composed of magnetite (Fe 3 O 4 ) or maghemite (-Fe 2 O 3 ), exhibiting a solid spherical shape

Ethics declarations Conflict of interest The authors declare that there exists no competing financial interest or personal relationships that could have appeared to influence the work reported in this paper