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Moving beyond broad plasma-based analyses to focus on specific organ systems, such as the brain, liver, and kidney, is likely to yield more targeted insights

Objective tracking prevents premature escalation to advanced interventions

Cocaine neurotoxicity and neurological damage stem from several mechanisms, including mitochondrial dysfunction (Poon et al., 2007), neuroinflammation (Moran et al., 2005), and autophagy ( 3.1 Vascular effects of cocaine Cocaine impairs vascular function by causing vasoconstriction, reducing cerebral blood flow, and decreasing tissue oxygenation

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