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A 2018 randomized controlled trial published in the European Journal of Clinical Nutrition tested this exact regimen in 48 participants consuming five standard drinks over four hours

However, there are multiple pathways that result in upregulation of COX-2 in brain neurons, including increased N-methyl-D-Aspartate (NMDA) receptor-dependent activity (230), cerebral ischemia, seizures, and diseases such as AD or PD (231)

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