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The following studies were excluded: review articles published more than 15 years ago, not found in PubMed or the databases, or not meeting the search criteria

For example, the CD47 protein on the surface of the erythrocyte membrane facilitates evasion of immune surveillance and enhances nanocarrier circulation [5], tumor-derived extracellular vesicles (EVs) aggregate more readily in tumor tissues when they are homologously targeted by integrins [6] and bacterial outer membrane vesicles (OMVs) stimulate antigen-presenting cells (APCs) and T cells to enhance antitumor immunity [7]

However, without comparing the patients to a similar group that does not receive the treatment, it is hard to know whether any improvement is due to placebo effect or to the treatment itself