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Microneedle-based platforms address critical limitations of conventional oral therapies for hyperuricemia, such as hepatic first-pass metabolism and poor bioavailability

Yet, despite their ability to sustain energetics and functionality in critical tissues, animals subjected to this fasting-refeeding cycle displayed lasting physiological changes, including a reduction in body size that persisted well into later life (Supplementary Fig

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TGF-beta signalling from cell membrane to nucleus through SMAD proteins