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cerevisiae strains C3G1-C3G10 and DHQC3G1DHQC3G10 (Supplementary Table 5) were restreaked on SC-ULH plates (1.47 g l 1 Synthetic Complete (Kaiser) Drop Out: Leu, His, Ura, 6.7 g l 1 yeast nitrogen base (without amino acids), 20 g l 1 d-(+)-glucose, 16 g l 1 agar) or SC-U plates (SC-ULH, 380 mg l 1 leucine, 76 mg l 1 histidine), respectively

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509 Clinical evidence indicates that the expression of ER stress-related proteins such as IRE1, PERK, and CHOP is reduced in SLE patients, while the levels of XBP1 and midbrain astrocyte-derived neurotrophic factor (MANF) are elevated, suggesting their potential role in disease development

Enzyme stability The cyclic disulfide bond structure makes it less likely to be degraded by proteases in adipose tissue, prolonging the action time