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PMN-MDSCs primarily suppress T cells by generating large amounts of reactive oxygen species (ROS) through NADPH oxidase 2 (NOX2) and peroxynitrite (ONOO-) (6, 10)

This observation is consistent with previous studies, which have indicated increased endogenous glutathione levels following treatment with ionizing radiation (34,35)

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have shown that measures taken to prevent glycocalyx degradation (subcutaneous injection of sulodexide (SDX), a highly purified patented product prepared from the porcine intestinal mucosa, consisting of 80% iduronylglycosaminoglycan sulfate, known as fast-moving heparin, and 20% dermatan sulfate) improves the survival of mice with sepsis (56)