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However, the nucleophilic capabilities of these residues were found to be relatively weak, leading to a substantial energy barrier in steps 1 and 4

Acta Neurol Taiwanica 22:112116 Rentea RM, Liedel JL, Welak SR, Cassidy LD, Mayer AN, Pritchard KA Jr, Oldham KT, Gourlay DM (2012) Intestinal alkaline phosphatase administration in newborns is protective of gut barrier function in a neonatal necrotizing enterocolitis rat model

The authors also labeled their nanoparticles with a radioactive moiety for image guided therapy of colon cancer [122]

Antioxid Redox Signal 9: 20272033 PedrajasJR,KosmidouE,MirandaVizueteA,GustafssonJA,WrightAP,SpyrouG (1999) Identification and functional characterization of a novel mitochondrial thioredoxin system in Saccharomyces cerevisiae