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For instance, in Arabidopsis , impaired MDAR4 function decreased the AsA/DHA ratio without affecting the ASC content, but substantially impaired plant oxidative stress tolerance (Eastmond, 2007)

Resistance to conventional chemotherapy or radiotherapy frequently involves upregulation of antioxidant pathways (e.g., the NRF2 and System Xc -GSH-GPX4 axis), rendering such cells highly vulnerable to ferroptosis ( ICIs ) can synergistically activate anti-tumor immune responses by promoting the release of tumor antigens and damage-associated molecular patterns ( This review aims to systematically analyze the molecular mechanisms of ferroptosis (lipid peroxidation drive, collapse of antioxidant defenses, and regulation of iron/lipid metabolism), its crosstalk with other cell death pathways, and key regulatory networks (e.g., NRF2, p53, Hippo-YAP pathways)

This is problematic, as treatments aiming to increase Hb levels by a few grams per deciliter are clearly more promising for the treatment of patients with thalassemia intermedia than for the treatment of transfusion-dependent patients

Furthermore, intramuscular injections carry higher risks, require a longer and thicker needle (which goes against everything we've just discussed), and can be significantly more painful