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Lipopolysaccharides are indispensable macromolecules for the growth and survival of Gram-negative bacteria, providing an effective permeability barrier at the environmental interface to cationic antimicrobial peptides and antibiotics used in clinical practice, while enhancing intracellular survival and contributing to the evasion of the immune defences by mimicry of host molecules

*Correspondence: Peizeng Yang, [email protected] These authors have contributed equally to this work This article was submitted to Molecular Medicine, a section of the journal Frontiers in Cell and Developmental Biology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Lipid hydroperoxidation assay Total lipids were extracted from the respective bacterial strains as described previously 50

They catalyzing S-glutathionylationa reversible modification that shields protein thiols from irreversible oxidation while modulating protein function ( GST transcription was progressively activated during ME induction, with a pronounced enrichment at stage III in the responsive cultivar Igri