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Exp Neurol 209:213223 Wang L, Yang HJ, Xia YY, Feng ZW (2010) Insulin-like growth factor 1 protects human neuroblastoma cells SH-EP1 against MPP+-induced apoptosis by AKT/GSK-3beta/JNK signaling

Effectively, the GSDMD-mediated pyroptosis process promotes the release of mtDNA

Finally, although HG106 was recently identified as a SLC7A11 inhibitor (Hu et al., 2020), whether it can act as a FIN remains to be further examined (so far, all other SLC7A11 inhibitors can induce ferroptosis)

Semaglutide and tirzepatide have FDA approved uses, while some other peptides discussed online or in wellness settings are not FDA approved drugs and may involve added safety and regulatory considerations